About
Joseph D. Etlinger, Ph.D.
Chair, Cell Biology and AnatomyProfessor, Cell Biology and Anatomy School of MedicineProfessor, Cell Biology and Anatomy Biomedical Sciences
Areas of Expertise
- Skeletal muscle growth and atrophy
- Molecular mechanisms
- Selectivity of intracellular proteolysis in erythroid and muscle cells
- Role of proteasomes and ubiquitin
- Spinal cord injury
- Pulmonary hypertension
Education
- B.S., Physics, Rensselaer Polytechnic Institute
- Ph.D., Biophysics, University of Chicago
- Postdoctoral Fellowship, Physiology and Biochemistry, Harvard Medical School
Honors and Awards
- Established Investigator of the American Heart Association
- Irma T. Hirschl Award, Principal Investigator on grants from NIH, NASA and MDA
Research
With Alfred L. Goldberg, Dr. Etlinger discovered non-lysosomal ATP-dependent proteolytic activity, credited by awardees of the 2004 Nobel Prize in chemistry, as the seminal observation revealing the proteasome/ubiquitin system. In subsequent studies, with his students and colleagues, novel factors involved in the regulation of this pathway including a ubiquitin ligase critical to pulmonary arterial hypertension were identified. Dr. Etlinger proposed how myofibrils turnover during muscle growth and atrophy and the roles of calcium, ATP, and beta-adrenergic receptors in these conditions. Finally, he identified modalities to improve recovery from spinal cord injury including beta-agonists, x-irradiation, and inhibitors of glucose toxicity.
| ( ! ) Warning: file_get_contents(https://tourowebapis.wearetouro.com/api/pubmed-api/filter?action=getAuthorPublications&fullName=etlinger%20JD): failed to open stream: HTTP request failed! HTTP/1.1 500 Internal Server Error in /srv/commonCodeNew/phpIncludes/commonFunctions.php on line 474 | ||||
|---|---|---|---|---|
| Call Stack | ||||
| # | Time | Memory | Function | Location |
| 1 | 0.0020 | 530840 | {main}( ) | .../etlinger-joseph-d.php:0 |
| 2 | 3.6452 | 1982632 | renderPubMedPublications( ) | .../etlinger-joseph-d.php:1455 |
| 3 | 3.6452 | 1982888 | file_get_contents ( ) | .../commonFunctions.php:474 |
| ( ! ) Warning: Invalid argument supplied for foreach() in /srv/commonCodeNew/phpIncludes/commonFunctions.php on line 479 | ||||
|---|---|---|---|---|
| Call Stack | ||||
| # | Time | Memory | Function | Location |
| 1 | 0.0020 | 530840 | {main}( ) | .../etlinger-joseph-d.php:0 |
| 2 | 3.6452 | 1982632 | renderPubMedPublications( ) | .../etlinger-joseph-d.php:1455 |
Publications
Teaching Responsibilities
- Medical Cell Biology and Anatomy
- Graduate Histology and Graduate Cell Biology
- Dental Histology
- Cell Biology Topics
- Journal Club
