Michal Laniado Schwartzman, M.Sc., Ph.D., joined the Department of Pharmacology in 1981 as a postdoctoral fellow on an NIH Fogarty Fellowship and rose to the rank of full professor in 1993. Dr. Schwartzman is a recipient of numerous awards including the Dean's Distinguished Research Award and has held continuous NIH funding since 1981. She has also served as a member of NIH study sections, NIH review panels and journal editorial boards. Dr. Schwartzman is currently the editor of the Journal Prostaglandins and Other Lipid Mediators.

Education

• B.Sc., Biology, Tel-Aviv University
• M.Sc., Biochemistry, Tel-Aviv University
• Ph.D., Biochemistry, Tel-Aviv University

Honors and Awards

• Fogarty International Fellowship
• Irma T. Hirschl Career Scientist Award
• Mathers Foundation Scientist Award
• The Tinsley Harrison Award for Cardiovascular Research
• The Dean's Distinguished Research Award

Research

Dr. Schwartzman is nationally and internationally recognized for her research which focuses on the role of eicosanoids of the cytochrome P450 pathway, primarily 20-HETE, in the regulation of vascular function, inflammation and metabolism in the areas of cardiovascular and metabolic diseases. The chemical structure, biological function and mechanism of action of some of these lipids have been identified in Dr. Schwartzman’s laboratory.

Currently, she is utilizing gene targeting, transgenic animals and human material to 1) elucidate the pathophysiological significance of 20-HETE in promoting disease; 2) identify the mechanisms underlying the bioaction of this vasoactive proinflammatory lipid; and 3) develop small molecules to block its action. Dr. Schwartzman has published more than 245 manuscripts in peer-reviewed journals, including Nature, Science, PNAS, JCI and Circulation Research.

Publications

• Fragner ML, Parikh MA, Jackson KA, et. al. "GPR75: A Newly Identified Receptor for Targeted Intervention in the Treatment of Obesity and Metabolic Syndrome." Cardiology in review, (), (2024) . doi: 10.1097/CRD.0000000000000711
• D'Addario CA, Matsumura S, Kitagawa A, et. al. "Global and endothelial G-protein coupled receptor 75 (GPR75) knockout relaxes pulmonary artery and mitigates hypoxia-induced pulmonary hypertension." Vascular pharmacology, 153(), (2023) 107235. doi: 10.1016/j.vph.2023.107235
• Pascale JV, Wolf A, Kadish Y, et. al. "20-Hydroxyeicosatetraenoic acid (20-HETE): Bioactions, receptors, vascular function, cardiometabolic disease and beyond." Advances in pharmacology (San Diego, Calif.), 97(), (2023) 229-255. doi: 10.1016/bs.apha.2023.01.002
• Hossain S, Gilani A, Pascale J, et. al. "Gpr75-deficient mice are protected from high-fat diet-induced obesity." Obesity (Silver Spring, Md.), 31(4), (2023) 1024-1037. doi: 10.1002/oby.23692
• Azcona JA, Tang S, Berry E, et. al. "Neutrophil-Derived Myeloperoxidase and Hypochlorous Acid Critically Contribute to 20-Hydroxyeicosatetraenoic Acid Increases that Drive Postischemic Angiogenesis." The Journal of pharmacology and experimental therapeutics, 381(3), (2022) 204-216. doi: 10.1124/jpet.121.001036
• Agostinucci K, Hutcheson R, Hossain S, et. al. "Blockade of 20-hydroxyeicosatetraenoic acid receptor lowers blood pressure and alters vascular function in mice with smooth muscle-specific overexpression of CYP4A12-20-HETE synthase." Journal of hypertension, 40(3), (2022) 498-511. doi: 10.1097/HJH.0000000000003038
• Akbari P, Gilani A, Sosina O, et. al. "Sequencing of 640,000 exomes identifies GPR75 variants associated with protection from obesity." Science (New York, N.Y.), 373(6550), (2021) . doi: 10.1126/science.abf8683

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Professional Service

• Chair, Appointment, Promotion and Tenure Committee
• Editor, Prostaglandins and Other Lipid Mediators (Elsevier)