Areas of Expertise

• Melanoma tumor biology
• Cardiology
• Immunology

Education

• M.S., University of Missouri-Columbia 
• Ph.D., University of Missouri-Columbia

Research

Dr. Hamby conducts research in three major areas: tumor biology, cardiology, and immunology. He has a longstanding interest in melanoma tumor biology and in recent years has worked on the development of biological cytotoxins that target tumor cells directly or their supporting blood supply. In the area of cardiology, Dr. Hamby is currently investigating the role of bone marrow-derived stem cells in the long-term clinical benefits of a non-invasive treatment for heart disease. Lastly, he is exploring the immune mechanisms underlying the protective effect of oligoribonucleotides (ORN) and other low molecular weight compounds released by bacteria in plant and animal hosts.

Publications

• Tartaglia JT, Eisenberg CA, DeMarco JC, et. al. "Mobilization of Endogenous CD34+/CD133+ Endothelial Progenitor Cells by Enhanced External Counter Pulsation for Treatment of Refractory Angina." International journal of molecular sciences, 25(18), (2024) . doi: 10.3390/ijms251810030
• Safai B, Wu AG, Hamby CV, et. al. "Prognostic Biomarkers in Melanoma: Tailoring Treatments to the Patient." The Journal of clinical and aesthetic dermatology, 14(12), (2021) 44-48.
• Huang X, Park H, Greene J, et. al. "IGF1R- and ROR1-Specific CAR T Cells as a Potential Therapy for High Risk Sarcomas." PloS one, 10(7), (2015) e0133152. doi: 10.1371/journal.pone.0133152
• Zanganeh S, Xu Y, Hamby CV, et. al. "Enhanced fluorescence diffuse optical tomography with indocyanine green-encapsulating liposomes targeted to receptors for vascular endothelial growth factor in tumor vasculature." Journal of biomedical optics, 18(12), (2013) 126014. doi: 10.1117/1.JBO.18.12.126014
• Blankenberg FG, Levashova Z, Goris MG, et. al. "Targeted systemic radiotherapy with scVEGF/177Lu leads to sustained disruption of the tumor vasculature and intratumoral apoptosis." Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 52(10), (2011) 1630-7. doi: 10.2967/jnumed.111.091629
• Ackerman R, Backer JM, Backer M, et. al. "SLT-VEGF reduces lung metastases, decreases tumor recurrence, and improves survival in an orthotopic melanoma model." Toxins, 2(9), (2010) 2242-57. doi: 10.3390/toxins2092242
• Levashova Z, Backer M, Hamby CV, et. al. "Molecular imaging of changes in the prevalence of vascular endothelial growth factor receptor in sunitinib-treated murine mammary tumors." Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 51(6), (2010) 959-66. doi: 10.2967/jnumed.109.072199

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