Areas of Expertise

• Genetics and Pathophysiology of Hypertension

Education

• Ph.D., Life Sciences, Devi Ahilya Vishwavidyalaya, Indore, India

Research

Dr. Jain’s laboratory is focused on genetic factors dictating the propensity of the population to develop hypertension and related diseased conditions. In particular, they study single nucleotide polymorphisms in the renin- angiotensin-aldosterone system (RAAS) with an emphasis towards the impact of this axis on the genesis of hypertension. With available NIH support, they are employing new engineered mouse lines to dissect differential regulation of target genes, whose polymorphisms have been identified in patients with hypertension. Specifically, the consequences of aging on the progression of renal and cardiovascular complications are tested in their experimental models.

Publications

• Pizzo E, Cervantes DO, Ripa V, et. al. "The cAMP/PKA signaling pathway conditions cardiac performance in experimental animals with metabolic syndrome." Journal of molecular and cellular cardiology, 196(), (2024) 35-51. doi: 10.1016/j.yjmcc.2024.09.002
• Pizzo E, Cervantes DO, Ketkar H, et. al. "Phosphorylation of cardiac sodium channel at Ser571 anticipates manifestations of the aging myopathy." American journal of physiology. Heart and circulatory physiology, 326(6), (2024) H1424-H1445. doi: 10.1152/ajpheart.00325.2023
• Ketkar H, Alqahtani M, Tang S, et. al. "Chronically hypertensive transgenic mice expressing human AT1R haplotype-I exhibit increased susceptibility to Francisella tularensis." Frontiers in microbiology, 14(), (2023) 1173577. doi: 10.3389/fmicb.2023.1173577
• Pizzo E, Berrettoni S, Kaul R, et. al. "Heart Rate Variability Reveals Altered Autonomic Regulation in Response to Myocardial Infarction in Experimental Animals." Frontiers in cardiovascular medicine, 9(), (2022) 843144. doi: 10.3389/fcvm.2022.843144
• Cervantes DO, Pizzo E, Ketkar H, et. al. "Scn1b expression in the adult mouse heart modulates Na(+) influx in myocytes and reveals a mechanistic link between Na(+) entry and diastolic function." American journal of physiology. Heart and circulatory physiology, 322(6), (2022) H975-H993. doi: 10.1152/ajpheart.00465.2021
• Mopidevi B, Kaw MK, Sivankutty I, et. al. "A polymorphism in intron I of the human angiotensinogen gene (hAGT) affects binding by HNF3 and hAGT expression and increases blood pressure in mice." The Journal of biological chemistry, 294(31), (2019) 11829-11839. doi: 10.1074/jbc.RA119.007715
• Jain S, Rana A, Jain K, et. al. "Age-Related Expression of Human AT1R Variants and Associated Renal Dysfunction in Transgenic Mice." American journal of hypertension, 31(11), (2018) 1234-1242. doi: 10.1093/ajh/hpy121

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Memberships and Affiliations

• American Heart Association
• The American Physiological Society
• New York Academy of Sciences