Daohong Lin, M.D., Ph.D., joined Dr. Wenhui Wang’s lab in the Department of Pharmacology at NYMC as a research fellow in March 2000 when she was a second-year Ph.D. student at Harbin Medical University, China. Her long-standing research interest has been focused on studying the regulation of inwardly rectifying potassium channels (Kir) in epithelial cells. During her post-doctoral training in Dr. Wang’s lab in 2005, Dr. Daohong studied the regulation of ROMK channel (Kir1.1), a key K channel for renal K secretion in the kidney. She has used molecular, protein chemistry, and electrophysiology approaches to study the roles of protein kinases, ubiquitination, and microRNA in mediating the effect of dietary K intake on ROMK channels. Additionally, she has observed that low K intake stimulated the ROMK ubiquitination and that protein tyrosine kinase inhibited ROMK by increasing ROMK internalization. After receiving the Scientific Development Grant from American Heart Association in 2011, Dr. Daohong was appointed as a tenure-track assistant professor in the Department of Pharmacology at NYMC. Since becoming an independent faculty member, Dr. Daohong’s research has focused on the regulation of Kir5.1(Kcnj16) on Kir4.1 (Kcnj10) channels in the kidney and got NIH R01 fundings in 2017 and 2023.

Areas of Expertise

• Renal Physiology

Education

• M.D., Clinical Medicine, Harbin Medical University
• M.S., Microbiology, Harbin Medical University
• Ph.D., Pharmacology, Harbin Medical University/New York Medical College

Honors and Awards

• Reviewer, Oct 12-13, 2023, NIH Kidney and Urological Systems Function and Dysfunction (KUFD) study section

Research

• Regulation of Kir4.1/Kir5.1 and renal potassium excretion

Publications

• Duan XP, Zheng JY, Xiao Y, Zhang CB, Lin DH, Wang WH. Angiotensin II-Type-1a Receptor and Renal K + Wasting during Overnight Low-Na + Intake. J Am Soc Nephrol. 2024 Nov 1;35(11):1478-1492. doi: 10.1681/ASN.0000000000000429. Epub 2024 Jun 24. PubMed PMID: 38913434; PubMed Central PMCID: PMC11543017.
• Duan XP, Zhang CB, Wang WH, Lin DH. Role of calcineurin in regulating renal potassium (K(+)) excretion: Mechanisms of calcineurin inhibitor-induced hyperkalemia. Acta Physiol (Oxf). 2024 Aug;240(8):e14189. doi: 10.1111/apha.14189. Epub 2024 Jun 11. Review. PubMed PMID: 38860527; PubMed Central PMCID: PMC11250626.
• Duan XP, Zheng JY, Jiang SP, Wang MX, Zhang C, Chowdhury T, Wang WH, Lin DH. mTORc2 in Distal Convoluted Tubule and Renal K + Excretion during High Dietary K + Intake. J Am Soc Nephrol. 2024 May 24;35(9):1149-63. doi: 10.1681/ASN.0000000000000406. [Epub ahead of print] PubMed PMID: 38788191; PubMed Central PMCID: PMC11387030.
• Zhang DD, Duan XP, Mutig K, Rausch F, Xiao Y, Zheng JY, Lin DH, Wang WH. Calcineurin inhibitors stimulate Kir4.1/Kir5.1 of the distal convoluted tubule to increase NaCl cotransporter. JCI Insight. 2023 Apr 10;8(7). doi: 10.1172/jci.insight.165987. PubMed PMID: 36821372; PubMed Central PMCID: PMC10132170.
• Murillo-de-Ozores AR, Carbajal-Contreras H, Magaña-Ávila GR, Valdés R, Grajeda-Medina LI, Vázquez N, Zariñán T, López-Saavedra A, Sharma A, Lin DH, Wang WH, Delpire E, Ellison DH, Gamba G, Castañeda-Bueno M. Multiple molecular mechanisms are involved in the activation of the kidney sodium-chloride cotransporter by hypokalemia. Kidney Int. 2022 Nov;102(5):1030-1041. doi: 10.1016/j.kint.2022.06.027. Epub 2022 Jul 21. PubMed PMID: 35870644; PubMed Central PMCID: PMC10411384.
• Lin DH, Duan XP, Zheng JY, Wang WH. Role of inwardly rectifying K+ channel 5.1 (Kir5.1) in the regulation of renal membrane transport. Curr Opin Nephrol Hypertens. 2022 Sep 1;31(5):479-485. doi: 10.1097/MNH.0000000000000817. Epub 2022 Jul 11. Review. PubMed PMID: 35894283.
• Wang WH, Lin DH. Inwardly rectifying K(+) channels 4.1 and 5.1 (Kir4.1/Kir5.1) in the renal distal nephron. Am J Physiol Cell Physiol. 2022 Aug 1;323(2):C277-C288. doi: 10.1152/ajpcell.00096.2022. Epub 2022 Jun 27. Review. PubMed PMID: 35759440; PubMed Central PMCID: PMC9291425.

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Professional Service

• AJP-Renal Physiology, Editorial Board Member
• Frontiers in Physiology Renal Epithelial and Transports, Editorial Board Member

Memberships and Affiliations

• American Physical Society (APS)

Teaching Responsibilities

• PSE
• Pharmacology