Julian M. Stewart, M.D., Ph.D., directs the Center for Hypotension, which has had NIH funding for 24 years. He is trained in medicine, integrative physiology, and computer-based biophysical methods.
Dr. Stewart's laboratory has been studying orthostatic intolerance in conscious humans for more than 20 years, with a particular focus on circulatory regulation in orthostatic intolerance (OI). Chronic OI is better known as postural tachycardia syndrome (POTS). His research has contributed to the literature regarding measurements of systemic vascular resistance, cardiac output, and venous capacitance as well as microvascular properties. Recently, Dr. Stewart's research has been focused on connections between hypocapnia, hypercapnia, hyperventilation, impaired cognition, cardiovagal baroreflexes, cerebral autoregulation, splanchnic vasoconstriction and venoconstriction, and enhanced sympathetic activity in OI patients.
Education
- Fellowship, Pediatric Cardiology, New York Hospital-Cornell University
- Residency, Physiology/Biophysics, NYU Medical Center
- M.D., University of Chicago
- Ph.D., University of Chicago
- A.B., Physics, Cornell University
- Postdoc, Pediatric Cardiology, New York Hospital-Cornell University
Areas of Expertise
- Pediatrics/Pediatric Cardiology
- Hypotension
- DOD Gulf War Syndrome
- CFS/Fibromyalgia
Research
Research interests include computational circulatory physiology, investigating vascular and cardiac properties in animal model systems, as well as during diagnostic procedures such as cardiac catheterization and flow-volume monitoring, and redistribution in critically ill infants and children. Correlative work studying the relation of cardiovascular properties to nitric oxide physiology is in progress. Recent work has also included connections of peripheral flow and muscle pump activity with osteoporosis, and contractual work with the Department of Defense related to muscular dystrophy.
Publications
- Tang EL, Eastwood L, Bujakowski J, et. al. "Assessment of UK healthcare workers' knowledge, attitudes and practice towards antibiotics, antibiotic use and antibiotic resistance: comparing findings from 2019 and 2024 national surveys." JAC-antimicrobial resistance, 7(6), (2025) dlaf205. doi: 10.1093/jacamr/dlaf205
- Rajagopal J, Jayanthi R, Stewart JP, et. al. "Transcatheter Aortic Valve Replacement in Patient With Extensive Aortic Dissection: Role of "Balloon Flossing"." Journal of the Society for Cardiovascular Angiography & Interventions, 4(10Part A), (2025) 103817. doi: 10.1016/j.jscai.2025.103817
- Marques E, Burr SP, Casey AM, et. al. "An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice." Nature communications, 16(1), (2025) 10222. doi: 10.1038/s41467-025-65023-4
- Brown LL, Wilkins ML, Pichon LC, et. al. "Pre-implementation Stage Research to Guide Trauma-Informed Care for Youth With HIV in the Southern US: A Multimethod Study." Journal of the International Association of Providers of AIDS Care, 24(), (2025) 23259582251382269. doi: 10.1177/23259582251382269
- Ali A, Courtney D, Broadbent L, et. al. "Preclinical Screening Platform Identifies Azatadine-Dimaleate as a Potent Repurposed Therapeutic Against SARS-CoV-2 Infection." Journal of medical virology, 97(11), (2025) e70713. doi: 10.1002/jmv.70713
- Stewart J, Anderson J, Mayne R, et. al. "Who is responsible for follow-up after critical illness? GP, ICU and patient perspectives." Critical care (London, England), 29(1), (2025) 489. doi: 10.1186/s13054-025-05724-w
- VanCompernolle M, Morris J, Calich HJ, et. al. "Vulnerability of marine megafauna to global at-sea anthropogenic threats." Conservation biology : the journal of the Society for Conservation Biology, (), (2025) e70147. doi: 10.1111/cobi.70147
Professional Service
- CDC-NIH Committee on Chronic Fatigue in Adolescents
- NIH/NIAID Special Emphasis Panel
- Ad Hoc Reviewer CVS-A
- Reviewer, Center for Interdisciplinary Cardiovascular Sciences
