Julian M. Stewart, M.D., Ph.D., directs the Center for Hypotension, which has had NIH funding for 24 years. He is trained in medicine, integrative physiology, and computer-based biophysical methods.
Dr. Stewart's laboratory has been studying orthostatic intolerance in conscious humans for more than 20 years, with a particular focus on circulatory regulation in orthostatic intolerance (OI). Chronic OI is better known as postural tachycardia syndrome (POTS). His research has contributed to the literature regarding measurements of systemic vascular resistance, cardiac output, and venous capacitance as well as microvascular properties. Recently, Dr. Stewart's research has been focused on connections between hypocapnia, hypercapnia, hyperventilation, impaired cognition, cardiovagal baroreflexes, cerebral autoregulation, splanchnic vasoconstriction and venoconstriction, and enhanced sympathetic activity in OI patients.
Education
- Fellowship, Pediatric Cardiology, New York Hospital-Cornell University
- Residency, Physiology/Biophysics, NYU Medical Center
- M.D., University of Chicago
- Ph.D., University of Chicago
- A.B., Physics, Cornell University
- Postdoc, Pediatric Cardiology, New York Hospital-Cornell University
Areas of Expertise
- Pediatrics/Pediatric Cardiology
- Hypotension
- DOD Gulf War Syndrome
- CFS/Fibromyalgia
Research
Research interests include computational circulatory physiology, investigating vascular and cardiac properties in animal model systems, as well as during diagnostic procedures such as cardiac catheterization and flow-volume monitoring, and redistribution in critically ill infants and children. Correlative work studying the relation of cardiovascular properties to nitric oxide physiology is in progress. Recent work has also included connections of peripheral flow and muscle pump activity with osteoporosis, and contractual work with the Department of Defense related to muscular dystrophy.
Publications
- White MC, Lange PT, Stewart J, et. al. "NEK2 drives pathogenesis, drug resistance, and LMP1 expression in EBV-positive non-Hodgkin lymphoma." Proceedings of the National Academy of Sciences of the United States of America, 123(20), (2026) e2535550123. doi: 10.1073/pnas.2535550123
- Hayden FG, Shinkai M, Clark TW, et. al. "Ensitrelvir for Covid-19 Postexposure Prophylaxis in Household Contacts." The New England journal of medicine, 394(19), (2026) 1905-1915. doi: 10.1056/NEJMoa2509306
- Stewart J, Ockert LE, Hawke T, et. al. "First insights into the Drivers of the Cloacal Microbiome of the Wild Platypus (Ornithorhynchus anatinus)." Microbial ecology, (), (2026) . doi: 10.1007/s00248-026-02788-1
- Semper A, Rigsby P, Otter A, et. al. "Evaluating the use of the first WHO International Standard for anti-SARS-CoV-2 immunoglobulin to harmonise the readouts between commercial SARS-CoV-2 binding antibody tests: the HARMONY multicentre calibration study." The Lancet. Microbe, (), (2026) 101329. doi: 10.1016/j.lanmic.2025.101329
- Stewart JD, Klein M, Jaupitre S, et. al. "Root traits correlate with crop rhizosphere microbiome diversity independent of legume relatedness." ISME communications, 6(1), (2026) ycag087. doi: 10.1093/ismeco/ycag087
- Panwar N, Stewart JE, Ibarra Caballero JR, et. al. "Characterizing fungal community shifts associated with Amauromyza karli Hendel (Diptera: Agromyzidae) infestation in quinoa." Frontiers in plant science, 17(), (2026) 1741091. doi: 10.3389/fpls.2026.1741091
- Stewart JE, Islam R, Meadows E, et. al. "GCN5L1-Mediated Lysine Acetylation Regulates Mitochondrial Bioenergetics and Redox Homeostasis in the Aged Heart." Antioxidants (Basel, Switzerland), 15(4), (2026) . doi: 10.3390/antiox15040481
Professional Service
- CDC-NIH Committee on Chronic Fatigue in Adolescents
- NIH/NIAID Special Emphasis Panel
- Ad Hoc Reviewer CVS-A
- Reviewer, Center for Interdisciplinary Cardiovascular Sciences
