Julian M. Stewart, M.D., Ph.D., directs the Center for Hypotension, which has had NIH funding for 24 years. He is trained in medicine, integrative physiology, and computer-based biophysical methods.
Dr. Stewart's laboratory has been studying orthostatic intolerance in conscious humans for more than 20 years, with a particular focus on circulatory regulation in orthostatic intolerance (OI). Chronic OI is better known as postural tachycardia syndrome (POTS). His research has contributed to the literature regarding measurements of systemic vascular resistance, cardiac output, and venous capacitance as well as microvascular properties. Recently, Dr. Stewart's research has been focused on connections between hypocapnia, hypercapnia, hyperventilation, impaired cognition, cardiovagal baroreflexes, cerebral autoregulation, splanchnic vasoconstriction and venoconstriction, and enhanced sympathetic activity in OI patients.
Education
- Fellowship, Pediatric Cardiology, New York Hospital-Cornell University
- Residency, Physiology/Biophysics, NYU Medical Center
- M.D., University of Chicago
- Ph.D., University of Chicago
- A.B., Physics, Cornell University
- Postdoc, Pediatric Cardiology, New York Hospital-Cornell University
Areas of Expertise
- Pediatrics/Pediatric Cardiology
- Hypotension
- DOD Gulf War Syndrome
- CFS/Fibromyalgia
Research
Research interests include computational circulatory physiology, investigating vascular and cardiac properties in animal model systems, as well as during diagnostic procedures such as cardiac catheterization and flow-volume monitoring, and redistribution in critically ill infants and children. Correlative work studying the relation of cardiovascular properties to nitric oxide physiology is in progress. Recent work has also included connections of peripheral flow and muscle pump activity with osteoporosis, and contractual work with the Department of Defense related to muscular dystrophy.
Publications
- Vo A, Shen LL, Pak I, et. al. "Association between Baseline Subfoveal Choroidal Thickness and Anatomical and Functional Outcomes in Geographic Atrophy." Ophthalmology science, 6(2), (2025) 100986. doi: 10.1016/j.xops.2025.100986
- Spencer DA, Gutierrez R, Guhaniyogi R, et. al. "Bayesian scalar-on-tensor regression using the Tucker decomposition for sparse spatial modeling." Biostatistics (Oxford, England), 26(1), (2024) . pii: kxaf029. doi: 10.1093/biostatistics/kxaf029
- Nicholls SJ, Ryan DH, Deanfield J, et. al. "Semaglutide and Hospitalizations in Patients With Obesity and Established Cardiovascular Disease: An Exploratory Analysis of the SELECT Randomized Clinical Trial." JAMA cardiology, (), (2025) . doi: 10.1001/jamacardio.2025.4824
- Aad G, Aakvaag E, Abbott B, et. al. "Evidence for the Dimuon Decay of the Higgs Boson in pp Collisions with the ATLAS Detector." Physical review letters, 135(23), (2025) 231802. doi: 10.1103/gzdh-p159
- Park ES, Smith RL, Xu X, et. al. "Accounting for Exposure Measurement Error in Gridded Air Pollution Estimates in Assessing the Association of PM(2.5) Exposures with Health Outcomes in Cohort Studies." Environmental science & technology, (), (2025) . doi: 10.1021/acs.est.4c13918
- Li X, Dan M, Liu D, et. al. "Coinfection with Fowl adenovirus serotypes 1 and 4 (FAdV-1 and -4) enhances FAdV-4 replication through FAdV-1-mediated upregulation of HSPA2 expression." Virulence, (), (2025) 2605751. doi: 10.1080/21505594.2025.2605751
- Lawrence LSP, Chugh BP, Stewart J, et. al. "Magnetic resonance imaging-guided linear accelerator arterial spin labelling reveals dynamics of highly perfused non-enhancing glioblastoma during radiotherapy." Physics and imaging in radiation oncology, 36(), (2025) 100870. doi: 10.1016/j.phro.2025.100870
Professional Service
- CDC-NIH Committee on Chronic Fatigue in Adolescents
- NIH/NIAID Special Emphasis Panel
- Ad Hoc Reviewer CVS-A
- Reviewer, Center for Interdisciplinary Cardiovascular Sciences
